Vasopressin (ADH):

Pituitary Hormone

   

 

SQ (!) DOSING

   
5-10 units Give BID to QID as ADH replacement in Diabetes Insipidus.
 

IVP DOSING

   

40 units

This is the dose given for V Fib OR pulseless V Tach.  If it doesn't work, you can try the Epinephrine again...  Note: the concentration in your drip is quite dilute...  It would take a 400cc bolus at that concentration.

 

INFUSION DOSING

   

This is the dosing we give for vasodilatory shock, usually 0.04 u/min.  Never titrated.

0.01-0.04 u/min
   

This is the indicated range for acute GIB.

0.02-0.06 u/min
   

This dose is for your brain dead patient.  It maintains vital organ perfusion until the time is right...

0.5-6.0 u/min
 

ADH is a naturally occurring pituitary hormone that promotes the reabsorption of H20 at the very end of the distal loop of Henle.  It cause vasoconstriction by directly stimulating peripheral smooth muscle receptors.  Constriction occurs just about everywhere except for where you naturally want it not to, causing ­ CPP, cerebral vasodilation, ­ cerebral O2 delivery, and ­ blood flow to vital organs, while ¯ cardiac O2 demand.  Besides VF/VT, ADH is also used for nonnephrogenic, nonpsychogenic diabetes insipidus, and severe GI hemorrhage.  

 

Side Effects: Arrhythmias, cardiac arrest, ­ myocardial ischemia, angina, ¯ CO, bronchospasm/constriction, HA, confusion, vertigo, N/V, eructation, abdominal cramps, diaphoresis, hives, skin pallor, and gangrene.  

 

Contraindicated: CAD, CHF, asthma, chronic nephritis with nitrogen retention, migraines, epilepsy, pregnancy, lactation.

Vasopressin In ICU
Vasopressin: Applications In Clinical Practice

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Copyright 2009, Samos Alixopulos, ICU RN