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Propofol: |
Anesthetic-Sedative |
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IVP DOSING |
| 20-30 mg |
This is 2-3cc, and is handy if you've got a patient thrashing, and can't wait 3 minutes for the infusion to kick-in and start working. |
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INFUSION DOSING |
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This is the range for maintainance of sedation. Some people really need more than others! 25cc/hr or more is quite common for giant people. A wonderful drug. Easy on, easy off!!! The way all drips should be... |
5-50 mcg/kg/min |
Propofol
is a rapidly acting IV sedative/hypnotic used in the ICU to keep intubated
patients safe and comfy.
Its mechanism of action is not known.
Propofol contains ethylenediamine-tetraacetic acid (EDTA) which is a
stron metal chelator, so one might consider supplimental zinc during prolonged
use. Propofol
is is suspended in fat, so concurrent lipid administration may need to be
reduced or eliminated.
Q
5-10min until all is right. Typical maintanance infusion is 5-50 mcg/kg/min,
though some patients prefer up to 150-300 mcg/kg/min.
Side
Effects: ¯
HR, ¯
BP >
BP, ¯
CO, respiratory acidosis, apnea,
involuntary
movements,
N/V, rash, pain at IV site, and hyperlipidemia.
Contraindicated:
ICP, impaired cerebral circulation, disorders of lipid metabolism.
Propofol contains egg lecithin, soybean oil, and glycerol, so that
patients with these allergies cannot have it.
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