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Propranolol: |
Non-Selective b-Blocker |
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IVP DOSING |
| 1-3 mg |
Give no faster than 1mg per minute! Continue to give every 5 minutes as needed until a maximum dose of 0.1 mg/kg has been reached. |
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INFUSION DOSING |
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This IS the dose range for a continuous infusion. |
1-3 mg/hr |
Propranolol is a non-selective b-blocker, used in a wide variety of situations including VT/VF , A fib/flutter, PSVT, HTN, angina, anxiety states, essential tremors, and prevention of migrains. Also used for acute anterior MI when there is BP & HR, big AMIs < 6hrs old, and chest pain or tachycardia that is due to excess sympathetic tone and stimulation. It reduces myocardial O2 demand, ¯ BP, ¯ force of contraction, and ¯ renin which prevents cerebral arterial vasodilation (¯ migraines). It undergoes extensive first-pass hepatic metabolism, and is highly lipid soluble, allowing it to easily pass through the BBB. Its adverse CNS effects make it less tolerable when ongoing therapy is required. It has a short half-life, and must therefore be given BID when in oral form.
Side
Effects: are ¯
BP, ¯
HR, CHF,
angina, acute pulmonary edema, bronchospasmdizziness, HA, N/V, fatigue, vivid
dreams and/or insomnia, hallucinations, depression, and dizziness.
CCBs may
SEs.
Contraindicated:
in pts with CHF, ¯
BP, ¯
HR, 2°
or 3°
AV block, or cardiogenic shock.
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