Epinephrine:

Natural Chatecholamine

 

b1 = b2  > a

 
 

1:1,000 = 1mg/cc  (Can you tell the difference?) 1:10,000 = 0.1mg/cc

 

IVP DOSING FOR CARDIAC ARREST

   
1 mg/10 cc

Someone [else] is doing chest compressions, you've given the 3 shocks, and the patient is still reaching towards the light.  This would be a good time to give "Epi."  Feel free to keep on giving more every 3 to 5 minutes between further shocks (just for fun).  For ETT administration, give 2-3mg in 10cc NS.

   

5 mg/10 cc

Known as HDE (High Dose Epi)...  Was in vogue for a while amongst a few rebels.  Still an option with an order.  Give 5mg 10mg, then 15mg in rapid sequence.

   

INFUSION DOSING

   

If it works (or more accurately, stops working), then hang a drip!  You do want another bite of that cookie you were eating before everything went to hell, right?  ...It's still sitting out there on top of the people magazine where you left it.

2-10 mcg/min
   

DOSING FOR ANAPHYLAXIS

   
0.3-0.5mg

Okay, this is where YOU give your patient a heart attack or a stroke if YOU draw from the wrong ampule...  Don't use the big guns for this one!!! You need 1:10,000! Read the label!!!

   

SQ DOSING FOR ASTHMA

   

"Say, doesn't this asthma patient SOUND just like that gardener we had in yesterday?  You know, the one who had been fighting with a bee over a Scarlet Begonia?  Same dosage, DIFFERENT concentration and route.  Use the 1:10,00 and give SQ,  DO NOT GIVE "EPI" IV FOR BRONCHIAL ASTHMA!!! 

0.3-0.5mg
   

Mainly used for VF, VT, PEA, and asystole.  Also used for its strong b2-effects (bronchodilation) in asthma and anaphylaxis, and in higher doses for its strong a-effects (vasoconstriction) to improve acute hypotension and bradycardia.  

 

Half Life: Effects can last from 1-4hrs IV, SQ/IM duration is unknown.  

 

Side Effects: include tachycardia, hypertension, arrhythmias, cerebral hemorrhage, dyspnea, pulmonary edema, headaches, anxiety, cold extremities.  Risk of inducing uterine contractions in late pregnancy. Less effective when b-receptors have been downregulated, as in severe CHF.  Contraindicated: tachydysrhythmias, CAD.

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Copyright 2009, Samos Alixopulos, ICU RN