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Benzodiazepine

 

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IVP DOSING

   
0.5-4 mg

Give slow IV over at least 2 minutes... I know you usually give it all at once, but too fast may actually give your room the wrong kind of peace and quiet!

 

INFUSION DOSING

   

1 to 10 mg/hr is real common.  If its for an older patient or a renal patient, you may find yourself obtaining a head CT 2 days after you turn it off...  That's why I prefer Propofol!  Hmm, still failing those CPAP trials, huh?

0.2-0.1 mg/kg/hr
 

Used for amnesia and sedation in the ICU, How does it work...? Onset is within minutes, but the effects lasts between 2-6 hours, so weaning is much more prolonged than with Propofol. 

Maintainance infusion runs around 0.2-10mg/kg/hr, higher for some.  

 

Side Effects: ¯­ HR, ¯ BP, ¯ RR, apnea, oversedation, amnesia, seizure-like activity (?), nystagmus, paradoxical reactions, HA, N/V, and hiccups.

 

Contraindicated: severe hypotension, shock, coma, acute angle-clsure glaucoma, and acute ETOH intoxication (they're drunk).

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Copyright 2009, Samos Alixopulos, ICU RN