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Norepinephrine: |
Naturally Occuring Chatecholemine |
|
b1 > a > b2 |
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INFUSION DOSING |
| Start at 2-8 mcg/min, and titrate as needed to maintain a good BP [for both you and your patient]. | 2-30 mcg/min |
Used
for cardiogenic and neurogenic shock. Is
especially indicated for septic shock. Especially beneficial for "warm" shock, when
significant peripheral vasodilation is present.
May be combined with PDE inhibitors to offset their hypotensive effects.
Half
Life: Effects end within 1-2
minutes after the infusion is stopped.
Side
Effects: AMI, anaphylaxis,
bradycardia, severe hypertension, arrhythmias, dyspnea, as well as worsening of
asthma symptoms. Decreases renal
perfusion, and therefore UO. May induce uterine contractions in late pregnancy.
Contraindicated: Hypovolemia, profound hypoxia or hypercapnia,
bronchospasm, ischemic heart disease, known thrombi (increases the risk of
peripheral and mesenteric thrombus mobilization). Extravasation causes tissue
necrosis.
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